USMLE Step 1 Question of the Day
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An otherwise healthy Kenyan man is prescribed trimethoprim-sulfamethoxazole for a urinary tract infection. He presents to the emergency department with jaundice, fatigue, and confusion. Which of the following might you see in the RBCs of a peripheral smear?
Correct Answer: A. Heinz bodies
G6PD deficiency is often asymptomatic until faced with an oxidative challenge, such as the drug TMP-SMX. It usually occurs in people of central African, Middle-Eastern, or Western Asian origin. The classic finding in RBCs is Heinz bodies (Answer A), which are collections of denatured hemoglobin. Howell-Jolly bodies are nuclear remnants in RBCs that remain due to failure of splenic sequestration in Sickle-cell disease. Basophilic stippling represents RNA collections that are most classically associated with lead poisoning. Auer rods are clumps of granular material diagnostic of acute myeloid leukemia (AML). Reed-sternberg bodies are the “owl-eyes” pathognomonic for Hodgkin’s lymphoma.
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Category: HistologyAn otherwise healthy Kenyan man is prescribed trimethoprim-sulfamethoxazole for a urinary tract infection. He presents to the emergency department with jaundice, fatigue, and confusion. Which of the following might you see in the RBCs of a peripheral smear?
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