USMLE Step 1 Question of the Day
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A 52-year-old female presents with chest pain associated with eating food. An endoscopic study shows ulceration in the lower esophagus. Histological examination of tissue from this area reveals mucosal ulceration, some blood, fibrin, and proliferation of blood vessels and fibroblasts. Many cells are undergoing mitoses, and most cells have prominent nucleoli. This histology most closely describes what process in this ulceration?
Correct Answer: C. Granulation tissue
A tissue undergoing repair requires regeneration of damaged cells and connective tissue replacement. Typically, granulation tissue (Answer C) is formed, characterized histologically by proliferating blood vessels and fibroblasts. Regenerating cells are characterized by mitoses and prominent nucleoli. This histological description should not be confused with dysplasia or malignancy.
Granulation tissue should not be confused with granuloma, which is a specific type of inflammation characterized by epithelioid cells, also known as activated macrophages.
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Category: HistologyA 52-year-old female presents with chest pain associated with eating food. An endoscopic study shows ulceration in the lower esophagus. Histological examination of tissue from this area reveals mucosal ulceration, some blood, fibrin, and proliferation of blood vessels and fibroblasts. Many cells are undergoing mitoses, and most cells have prominent nucleoli. This histology most closely describes what process in this ulceration?
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