USMLE Step 1 Question of the Day
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Question:
A 46 year old diabetic woman presents with intense nausea for 2 weeks duration. She is subsequently diagnosed with diabetic gastroparesis and started on metoclopramide as an anti-emetic. Which of the following drugs has a similar mechanism of action as that of metoclopramide?
Correct Answer: A. Prochlorperazine
Metoclopramide is a D2 receptor antagonist that increases gastrointestinal contractility and motility as well as increases tone in the lower esophageal sphincter. Prochlorperazine (choice A) is also a D2 receptor antagonist and is used as an anti-emetic.
Dronabinol (choice B) is a cannabinoid and is used as a centrally acting anti-emetic.
Aprepitant (choice C) is a centrally acting anti-emetic that selectively antagonizes human substance P and neurokinin 1 receptors. Ondansetron (choice D) is a centrally acting anti-emetic that selectively antagonizes 5-HT3 receptors.
Cisapride (choice E) acts through serotonin receptors to increase ACh release in the myenteric plexus, promoting gastric motility. It is currently banned from U.S. markets due to its toxicity of cardiac arrhythmias.
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Category: PharmacologyA 46 year old diabetic woman presents with intense nausea for 2 weeks duration. She is subsequently diagnosed with diabetic gastroparesis and started on metoclopramide as an anti-emetic. Which of the following drugs has a similar mechanism of action as that of metoclopramide?
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