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Question:
Burkitt’s lymphoma is characterized by the rapid proliferation of non-cleaved B cell lymphocytes. Which chromosomal translocation is commonly found in patients with Burkitt’s lymphoma?
Correct Answer: A. t(8;14)
The 8 to 14 translocation is well known to cause cases of Burkitt’s lymphoma by interfering with the normal function of the c-Myc gene (normally present on chromosome 8). Other possibilities include t(2;8) and t(8;22).
t(14;18) causes follicular B cell lymphomas. t(14;21) and t(21;22) are examples of Robertsonian translocations (involving chromosome 21) which cause Down Syndrome. Trisomy 21 causes Down Syndrome and is not a translocation.
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Category: GeneticsBurkitt’s lymphoma is characterized by the rapid proliferation of non-cleaved B cell lymphocytes. Which chromosomal translocation is commonly found in patients with Burkitt’s lymphoma?
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