Question 63

Question:

Chronic cocaine consumption diminishes one’s reward pathway. Repeated use becomes necessary to maintain reward, thus leading to addiction. Cocaine increases synaptic concentrations of which of the following neurotransmitters?

Correct Answer: C.  Norepinephrine and Dopamine

Cocaine binds to the monoamine uptake transporter and blocks reuptake at the synaptic cleft of monoamines–dopamine, norepinephrine, and serotonin. The higher concentration of dopamine specifically, results in downregulation of dopaminergic receptors at the post-synaptic membrane. The decreased dopaminergic signaling during normal physiological conditions is what leads to diminished reward and addiction.