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Question:
An 88-year-old female presents to the ER with generalized jaundice and dark urine. A blood sample is taken and reveals dramatically increased levels of conjugated bilirubin. What is the likely diagnosis?
Correct Answer: A. Biliary obstruction
The increase of conjugated bilirubin rules out the causes of unconjugated hyperbilirubinemias (glucuronyl transferase deficiency, hematoma, and increased hemolysis). Reduced hepatic bilirubin uptake would result in decreased blood levels, not increased. Crigler-Najjar syndrome and Gilbert syndrome are examples of glucuronyl transferase deficiencies.
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Category: PathophysiologyAn 88-year-old female presents to the ER with generalized jaundice and dark urine. A blood sample is taken and reveals dramatically increased levels of conjugated bilirubin. What is the likely diagnosis?
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