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Question:
Sickle-cell anemia can be caused by a single amino-acid substitution in the beta chain of the hemoglobin molecule. Individuals who are homozygous for this trait will be at greater risk of anemic complications. Which of the following pathogens most likely increases the risk of an aplastic crisis in these patients?
Correct Answer: C. Parvovirus B19
Parvovirus B19 is known to induce aplastic crisis in patients with sickle cell disease. This virus is known as an “erythrovirus” because of its ability to invade red blood cell precursors in the bone marrow. Of note, the same virus is also a culprit of the childhood disease, erythema infectiosum, and in pregnant women, hydrops fetalis.
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Category: PathophysiologySickle-cell anemia can be caused by a single amino-acid substitution in the beta chain of the hemoglobin molecule. Individuals who are homozygous for this trait will be at greater risk of anemic complications. Which of the following pathogens most likely increases the risk of an aplastic crisis in these patients?
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