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USMLE Step 1 Questions
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Question:
A researcher performs immunohistochemical analysis on a blood sample from a patient. The researcher notices a large number of cells which stain for CD19, CD20, and IgM on their cell surface. What kind of cells are these?
Correct Answer: A. B cells
While most cells express a wide variety of proteins on their cell surface, the ones commonly used to identify cells of the immune system are as follows:
Helper T cells: CD4, TCR, CD3, CD28
Cytotoxic T cells: CD8, TCR, CD3
B cells: IgM or IgD, CD19, CD20
Plasma cells: IgG
NK cells: CD16, CD56, receptors for MHC I
Macrophages: MHC II, CD14
Antigen Presenting Cells (APCs): MHC IIWhen studying for the exam, only the most glaring markers are important. For instance, IgM should have immediately signaled B-cell (even if you did know about CD19 and CD20).
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Category: ImmunologyA researcher performs immunohistochemical analysis on a blood sample from a patient. The researcher notices a large number of cells which stain for CD19, CD20, and IgM on their cell surface. What kind of cells are these?
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