Quiz-summary
0 of 1 questions completed
Questions:
- 1
Information
USMLE Step 1 Questions
You have already completed the quiz before. Hence you can not start it again.
Quiz is loading...
You must sign in or sign up to start the quiz.
You have to finish following quiz, to start this quiz:
Results
Time has elapsed
You have reached 0 of 0 points, (0)
Categories
- Molecular Biology 0%
-
Question:
A 13-year-old female presents with her mother requesting information about the mechanism by which human papillomavirus (HPV) increases the risk of cervical carcinoma. Which of the following statements is true regarding HPV-associated cervical carcinoma?
Correct Answer: D. E7 inhibits the retinoblastoma (Rb) gene product
The carcinogenic effects of HPV types 16 and 18 are primarily associated with viral antigens E6 and E7. E6 promotes cervical carcinoma through inhibition of the tumor suppressor p53. E7 does so via inhibition of the retinoblastoma (Rb) gene product, which disinhibits E2F and promotes transcription and cell proliferation.
E6 does not influence E2F-mediated transcription (A); rather, E6 works by inhibiting p53.
E7 activates E2F-mediated transcription as described above; it does not inhibit it (B).
E6 does not activate the Rb gene product (C); rather, it inhibits p53.
E6 inhibits p53; activation of p53 (E) would decrease the risk of carcinoma, it would not promote carcinogenicity.
- 1
- Answered
- Review
-
Question 1 of 1
1. Question
Category: Molecular BiologyA 13-year-old female presents with her mother requesting information about the mechanism by which human papillomavirus (HPV) increases the risk of cervical carcinoma. Which of the following statements is true regarding HPV-associated cervical carcinoma?
Correct
Incorrect
