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USMLE Step 1 Questions
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The thrombolytic effect of tissue plasminogen activator depends on which of the following?
Correct Answer: E. Presence of fibrin at the site of the thrombus
Activated plasminogen (plasmin) degrades fibrin to fibrin split products.
(A) Heparin activates antithrombin III, which decreases the activity of IIa and Xa.
(B) Aspirin inhibits cyclooxygenase and thereby prostaglandin production by platelets.
(C) Factor II (prothrombin) is the inactive form of IIa (thrombin).
(D) TPA action is not dependent on fibrinogen concentration.
1. QuestionCategory: Pharmacology
The thrombolytic effect of tissue plasminogen activator depends on which of the following?Correct