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USMLE Step 1 Questions
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A 22-year-old male is started on haloperidol while inpatient. Which of the following long-term adverse effects can most likely be attributed to haloperidol use?
Correct Answer: A. Tardive dyskinesia
Haloperidol is a high-potency typical antipsychotic. Unlike low-potency antipsychotics such as chlorpromazine, haloperidol has a much stronger adverse effect profile due to its high affinity for D2 receptors. Tardive dyskinesia is due to the strong dopamine receptor blockade. The blockade leads to long-term up-regulation of D2 receptors and the resultant hyperkinesis.
Excess salivation would be due to stimulation of cholinergic receptors. Antihistamine effects, in fact, include anti-nausea (antiemetic) and decreased itching (pruritus). Hypotension would be expected with alpha-1 blockade.
1. QuestionCategory: Pharmacology
A 22-year-old male is started on haloperidol while inpatient. Which of the following long-term adverse effects can most likely be attributed to haloperidol use?Correct