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Question:
An otherwise healthy 55-year-old Asian American man is given isoniazid and vitamin B6 (pyridoxine) after conversion of his PPD skin test. An x-ray of the chest shows no abnormalities. Four weeks later, he develops abdominal pain and jaundice. Which of the following is the most likely explanation?
Correct Answer: C. Isoniazid-induced hepatitis
Hepatotoxicity is a well known side effect of isoniazid. Pyridoxine is given with isoniazid to help prevent B6 deficiency and neurotoxicity. The proximity of this man’s symptoms to starting isoniazid, normal chest x-ray, and lack of exposure make tuberculosis and hepatitis B unlikely. Cholecystitis is not a well-known toxicity of pyridoxine and jaundice is not a typical feature of cholecystitis.
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Category: PharmacologyAn otherwise healthy 55-year-old Asian American man is given isoniazid and vitamin B6 (pyridoxine) after conversion of his PPD skin test. An x-ray of the chest shows no abnormalities. Four weeks later, he develops abdominal pain and jaundice. Which of the following is the most likely explanation?
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