Quiz-summary
0 of 1 questions completed
Questions:
- 1
Information
USMLE Step 1 Questions
You have already completed the quiz before. Hence you can not start it again.
Quiz is loading...
You must sign in or sign up to start the quiz.
You have to finish following quiz, to start this quiz:
Results
Time has elapsed
You have reached 0 of 0 points, (0)
Categories
- Pathophysiology 0%
-
Question:
A 68-year-old man has had low back pain over the past 2 months. Laboratory studies show a normochromic, normocytic anemia and azotemia. Serum and urine calcium concentrations are abnormally increased, and urinalysis shows excessive protein (4+) and proteinaceous casts. Bone marrow examination is most likely to show uncontrolled proliferation of which of the following cells?
Correct Answer: D. Plasma cells
The patient described has multiple myeloma, which is characterized by proliferation of plasma cells and hyperproduction of monoclonal light chains (Bence-Jones proteins). Accumulation at the renal tubules causes renal insufficiency. MM also causes bone destruction, both from marrow expansion and stimulation of osteoclasts. This causes hypercalcemia, which also contributes to renal dysfunction. As with any leukemia, other cell lines are suppressed, causing anemia and thrombocytopenia.
- 1
- Answered
- Review
-
Question 1 of 1
1. Question
Category: PathophysiologyA 68-year-old man has had low back pain over the past 2 months. Laboratory studies show a normochromic, normocytic anemia and azotemia. Serum and urine calcium concentrations are abnormally increased, and urinalysis shows excessive protein (4+) and proteinaceous casts. Bone marrow examination is most likely to show uncontrolled proliferation of which of the following cells?
Correct
Incorrect
