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Question:
Two chemicals are isolated from the body. When administered at the same time, these chemicals induce gastric acid secretion that is four times as great as that induced by either one alone. The two chemicals are most likely to be which of the following?
Correct Answer: C. Gastrin and histamine
Gastrin and histamine (choice C) both result in increased HCl secretion from parietal cells. Gastrin is produced by the G cells of the antrum and duodenum, and it stimulates parietal cells, as well as increases histamine release from enterochromaffin cells. Parietal cells also have receptors for histamine, which stimulate them to secrete gastric acid.
Acetylcholine will increase gastric acid secretion, but secretin (choice A and E) stimulates secretion of bicarbonate from the pancreas, neutralizing acid.
Cholecystokinin (choice B and E) stimulates gallbladder contraction and pancreatic enzyme secretion.
Vasoactive intestinal polypeptide (choice D) stimulates water and electrolyte secretion from the intestines via cAMP.
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Category: PhysiologyTwo chemicals are isolated from the body. When administered at the same time, these chemicals induce gastric acid secretion that is four times as great as that induced by either one alone. The two chemicals are most likely to be which of the following?
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