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Question:
A 19-year-old college student presents to the sexual health clinic with a painless open lesion on his penis. An antibiotic is prescribed and the patient’s symptoms soon disappear. The most likely antibiotic functions by interfering with which of the following cellular components?
Correct Answer: C. Cell wall peptidoglycans
This student has the classic presentation of “chancre” from primary syphilis. The treatment of choice is still Penicillin G in non-allergic patients. Penicillins work by blocking formation of the cell wall that is made up of cross-linked peptidoglycans. Trimethoprim and pyrimethamine are folate inhibitors that block DHFR. Folate is needed for DNA replication of bacteria. Fluoroquinolones block DNA gyrase, needed to transcribe bacterial proteins. Macrolides and clindamycin block the 50S ribosome needed to elongate bacterial proteins. Aminoglycosides and tetracyclines block the 30S ribosome.
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1. Question
Category: MicrobiologyA 19-year-old college student presents to the sexual health clinic with a painless open lesion on his penis. An antibiotic is prescribed and the patient’s symptoms soon disappear. The most likely antibiotic functions by interfering with which of the following cellular components?
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