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A 10-year-old child presents with a persistent sinus infection. Over the course of the last 5 years, the patient has had several dozen sinus and upper respiratory infections. Blood tests reveal abnormally low levels of IgA immunoglobulin, but normal levels of other isotypes. This patient’s recurrent infections are most likely due to a defect in which of the following?
Correct Answer: C. Mucosal immunity
IgA deficiency is the most common selective immunoglobulin deficiency. IgA is the main immunoglobulin isotype mediating mucosal immunity. IgA does not play a major role in fixing complement, opsonizing bacteria, mast cell activation, or neutrophil activation.
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Category: ImmunologyA 10-year-old child presents with a persistent sinus infection. Over the course of the last 5 years, the patient has had several dozen sinus and upper respiratory infections. Blood tests reveal abnormally low levels of IgA immunoglobulin, but normal levels of other isotypes. This patient’s recurrent infections are most likely due to a defect in which of the following?
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