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Question:
A 78-year-old male experiences a hypertensive emergency and is given sodium nitroprusside intravenously. This patient’s nitric oxide levels can be monitored by which of the following laboratory tests?
Correct Answer: C. Serum thiocyanate levels
Nitroprusside is non-enzymatically transformed into cyanide to form cyanomethemoglobin. The cyanide is then metabolized to thiocyanate in the plasma. This assay can assess the effectiveness of therapy. Plasma nitroprusside concentration is incorrect because the half-life of the drug is usually too short to make this a meaningful test, and the other choices are biochemically and physiologically not feasible.
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Category: PharmacologyA 78-year-old male experiences a hypertensive emergency and is given sodium nitroprusside intravenously. This patient’s nitric oxide levels can be monitored by which of the following laboratory tests?
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