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USMLE Step 1 Questions
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Question:
A researcher studying a rare genetic disease finds that patients with the disease are missing both copies of a gene. This gene encodes a protein containing seven-helix transmembrane domains. Which type of protein is this most likely to be?
Correct Answer: A. G protein-coupled receptor
The G-protein coupled receptors (A) all contain seven transmembrane segments. Importantly, all metabotropic receptors span the cell membrane and contain cytoplasmic and extracellular faces.
The other molecules mentioned are all membrane-bound proteins, but they do not contain seven transmembrane helices.
The basic structure of MHC Class II (B) receptors, and T-cell (D) and Toll Like Receptors (E) should be familiar. They contain regions for ligand docking, but do not span the host cell’s membane multiple times.
The Na/K ATPase (C) is a bidrectional active ion passing channel , that contains much more structural complexity than any of the other choices.
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Category: BiochemistryA researcher studying a rare genetic disease finds that patients with the disease are missing both copies of a gene. This gene encodes a protein containing seven-helix transmembrane domains. Which type of protein is this most likely to be?
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