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Question:
An 80 year-old woman with metastatic vulvar carcinoma has marked temporal wasting and has lost 30 lbs over the last 2 months. Which cytokine is thought to contribute to the cachexia seen in advanced cancer?
Correct Answer: E. TNF-alpha
TNF-alpha, also called cachectin, is an acute phase reactant secreted mainly by macrophages. Chronically elevated levels of TNF-alpha cause cachexia, which is characterized by weight loss, muscle atrophy (usually most noticeable in the temporal region), weakness, and anorexia. It is also important to remember that septic shock is also mediated through TNF-alpha.
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Category: ImmunologyAn 80 year-old woman with metastatic vulvar carcinoma has marked temporal wasting and has lost 30 lbs over the last 2 months. Which cytokine is thought to contribute to the cachexia seen in advanced cancer?
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